Program Implementation
Three-Phase Implementation of the GTL Program
GTL is following a roadmap to do the critical science to establish systems biology; to develop the necessary tools, resources, and facilities; and to complete the transformation to true systems biology aimed at mission applications. The strategy is divided into three distinct phases:
- Genomics to Systems Biology. Transition from genomics to systems biology will include key proof-of-principle experiments in systems biology and technology prototyping and piloting that will create the science and technology base and begin to train a community of scientists in systems biology. The design, R&D, and early deployment of critical computing and information tools and infrastructure will provide the necessary foundation for data management, analysis, and modeling. Intense planning activities involving scientists, technologists, and mission programs will support the conceptualization, design, R&D, and construction of GTL production facilities.
- Fundamental Research Technology Integration and Scaleup. Vertically integrated centers will provide an engine for dramatically accelerating the study of microbial and plant systems and for discovering and developing predictive systems understanding—ultimately reducing the time for analysis from years to months.
- Biological Systems Knowledge for DOE Applications. Knowledge and capabilities developed in GTL will be provided for rapid and complete systems studies of important problems in science and for useful applications. This knowledge and these capabilities will position GTL to rapidly transform new science into revolutionary new processes and products to help meet critical DOE national needs.
GTL Fundamental Research, Technologies, and Applications Roadmap
| Genomics to Systems Biology Phase |
Fundamental Research Technology Integration and Scaleup Phase |
Biological Systems Knowledge for DOE Applications Phase
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| Science Base | ||
|---|---|---|
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Genomics to systems biology
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High-throughput study of key systems and processes
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Integrated knowledgebase for designing mission solutions
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| Technologies, Computing, and Research Centers | ||
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Advanced technology development and testing
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Centers’ operations: Comprehensive data
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Facilities applied to engineered systems
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| Applications of Mission Science | ||
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Key systems chosen for mission interest
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Mission model systems analysis begun
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Fully engineered systems designed and developed
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