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Genomic Science Program

Systems Biology for Energy and the Environment

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Genomic Science Program

Genome Glossary

A glossary of genetic terms including acronyms and abbreviations.

- Term Definition
abiotic Abiotic Non-living chemical and physical factors (e.g., soil, water, air, temperature, and sunlight) in the environment that affect ecosystems.
additivegeneticeffects Additive genetic effects When the combined effects of alleles at different loci are equal to the sum of their individual effects.
See also: complex trait
adenine Adenine (A) A nitrogenous base, one member of the base pair AT (adenine-thymine).
See also: base pair, nucleotide
adsorption Adsorption Accumulation of molecules or cells on the surface of a substance.
aerobic Aerobic Requiring oxygen.
aerosols Aerosols Airborne solid or liquid particles (typically no larger than a few micrometers) that can remain in the atmosphere for hours to days. Aerosols impact climate by scattering or absorbing radiation, initiating cloud formation, or altering the optical properties of clouds.
albedo Albedo Proportion of light or radiation reflected by a surface.
alfisols Alfisols Fertile soils in temperate forests with an underlying clay horizon.
algae Algae Photosynthetic, aquatic, eukaryotic organisms that contain chlorophyll but lack terrestrial plant structures (e.g., roots, stems, and leaves). Algae can exist in many sizes ranging from single cells to giant kelps several feet long.
algorithm Algorithm Formal set of instructions that tells a computer how to solve a problem or execute a task. A computer program typically consists of several algorithms.
allele Allele One of two or more forms of a gene or a genetic region (generally containing a group of genes). A population or species of organisms typically includes multiple alleles at each locus distributed among various individuals; except very rarely, each individual can have only two alleles at a given locus. Allelic variation at a locus is measurable as the number of alleles (polymorphism) present, or the proportion of heterozygotes in the population.
See also: locus, gene expression
allogeneic Allogeneic Variation in alleles among members of the same species.
alternativesplicing Alternative splicing Different ways of combining a gene's exons to make variants of the complete protein
aminoacid Amino acid Any of a class of 20 molecules that are combined to form proteins in living things. The sequence of amino acids in a protein and hence protein function are determined by the genetic code.
amplification Amplification An increase in the number of copies of a specific DNA fragment; can be in vivo or in vitro.
See also: cloning, polymerase chain reaction
anaerobic Anaerobic Lacking or not requiring oxygen.
andisols Andisols Volcanic soils containing ash and volcanic glass.
annotation Annotation Adding pertinent information such as putative gene product function or other commentary to the database entry of raw sequence of DNA bases or amino acid sequence.
See also: bioinformatics
anthropogenic Anthropogenic Resulting from human activity.
antisense Antisense Nucleotide sequence exactly opposite to an mRNA molecule made through transcription; under given circumstances an antisense oligonucleotide binds to the mRNA molecule to prevent a protein from being made.
See also: transcription
archaea Archaea Single-celled prokaryotic microbes that are structurally and metabolically similar to bacteria but share some features of their molecular biology with eukaryotes. The archaea are a distinct branch of life from the Bacteria and Eukarya.
aridisols Aridisols Dry desert soils with a prominent clay horizon.
arrayedlibrary Arrayed library Individual primary recombinant clones (hosted in phage, cosmid, YAC, or other vector) that are placed in two-dimensional arrays in microtiter dishes. Each primary clone can be identified by the identity of the plate and the clone location (row and column) on that plate. Arrayed libraries of clones can be used for many applications, including screening for a specific gene or genomic region of interest.
See also: library, genomic library, gene chip technology
assembly Assembly Putting sequenced fragments of DNA into their correct chromosomal positions.
atomicforcemicroscopy Atomic force microscopy Technique that uses a mechanical probe to characterize and magnify surface features with atomic detail.
ATPadenosinetriphosphate ATP (adenosine triphosphate) A multifunctional nucleotide responsible for cellular energy transfer and storage.

autoradiography Autoradiography A technique that uses X-ray film to visualize radioactively labeled molecules or fragments of molecules; used in analyzing length and number of DNA fragments after they are separated by gel electrophoresis.
autotroph Autotroph An organism that biochemically synthesizes its own organic materials from inorganic compounds using light or chemical energy.
axenic Axenic Culture of an organism that is entirely free of all other "contaminating" organisms. Axenic culture is an important tool for the study of symbiotic and parasitic organisms in a controlled manner.
backcross Backcross A cross between a eukaryote that is heterozygous for alleles obtained from two parental strains and a second eukaryote from one of those parental strains. Also used to describe the breeding protocol of an outcross followed by a backcross.
bacteria Bacteria Single-celled prokaryote, typically without a discrete, membrane-bound nucleus.
bacterialartificialchromosome Bacterial artificial chromosome (BAC) A vector used to clone DNA fragments (100- to 300-kb insert size; average, 150 kb) in Escherichia coli cells. Based on naturally occurring F-factor plasmid found in the bacterium E. coli.
See also: cloning vector
bacteriophage Bacteriophage See: phage
bacterioplankton Bacterioplankton Bacteria that inhabit marine and freshwater environments.
base Base One of the molecules that form DNA and RNA molecules.
See also: nucleotide, base pair, base sequence
basepair Base pair (bp) Two nitrogenous bases (adenine and thymine or guanine and cytosine) held together by weak bonds. Two strands of DNA are held together in the shape of a double helix by the bonds between base pairs.
basesequence Base sequence The order of nucleotide bases in a DNA molecule; determines structure of proteins encoded by that DNA.
basesequenceanalysis Base sequence analysis A method, sometimes automated, for determining the base sequence.
Bayesianapproach Bayesian approach Use of statistical methods that assign probabilities or distributions to future events based on knowledge of prior events.
biochar Biochar Biomass-derived black carbon.
biogeochemicalmodel Biogeochemical model A type of ecosystem model used to represent biologically mediated transformations and flows of carbon and other materials within an environment.
biogeochemistry Biogeochemistry Study of how interactions among biological and geochemical processes influence the global cycling of such essential elements as carbon, nitrogen, phosphorus, and sulfur.
biogeographicalmodel Biogeographical model A type of ecosystem model used to determine how populations in a particular region change over long time scales.
bioinformatics Bioinformatics The science of managing and analyzing biological data using advanced computing techniques. Especially important in analyzing genomic research data.
See also: informatics
biologicalpump Biological pump Collection of biological ocean processes that regulate the uptake, storage, transformation, and release of carbon.
biomasscellulosic Biomass (cellulosic) Plant stalks, trunks, stems, and leaves.
biome Biome A terrestrial region (e.g., grasslands, tropical forests) characterized by dominant vegetation and climate characteristics in terrestrial ecosystems. In aquatic environments, a biome is defined by a particular range of depths and biogeochemical properties.
biopolymer Biopolymer A large biological molecule formed by the linking together of smaller subunit molecules.
bioremediation Bioremediation The use of biological organisms such as plants or microbes to aid in removing hazardous substances from an area.
biosequestration Biosequestration Biologically mediated uptake and conversion of carbon dioxide to inert, long-lived, carbon-containing materials.
biosphere Biosphere All living organisms.
biotechnology Biotechnology A set of biological techniques developed through basic research and now applied to research and product development. In particular, biotechnology refers to the use by industry of recombinant DNA, cell fusion, and new bioprocessing techniques.
biotic Biotic Any living component that affects another organism. Biotic components include plants, animals, fungi, and bacteria.
blast BLAST Basic Local Alignment Search Tool. Computer program that, when given any nucleotide or amino acid (protein) sequence, returns similar sequences retrieved from a chosen query database, usually the non-redundant database which houses all submitted DNA or Protein sequences without duplication of a given sequence.
bole Bole Stem or trunk of a tree.
C3plant C3 plant Plants (e.g., soybean, wheat, and cotton) whose carbon-fixation products have three carbon atoms per molecule. Compared with C4 plants, C3 plants show a greater increase in photosynthesis with a doubling of CO2 concentration and less decrease in stomatal conductance, which results in an increase in leaf-level water use efficiency.
C4plant C4 plant Plants (e.g., maize and sorghum) whose carbon fixation products have four carbon atoms per molecule. Compared with C3 plants, C4 plants show little photosynthetic response to increased CO2 concentrations above 340 ppmv but show a decrease in stomatal conductance, which results in an increase in
photosynthetic water use efficiency.
candidategene Candidate gene A gene located in a chromosome region suspected of being involved in a given trait or function.
See also: positional cloning, protein
capillaryarray Capillary array Gel-filled silica capillaries used to separate fragments for DNA sequencing. The small diameter of the capillaries permit the application of higher electric fields, providing high speed, high throughput separations that are significantly faster than traditional slab gels.
carbondioxideCO2 Carbon dioxide (CO2) Gas that is an important part of the global carbon cycle. CO2 is emitted from a variety of processes (e.g., cellular respiration, biomass decomposition, and fossil fuel use) and taken up primarily by the photosynthesis of plants and microorganisms where it can become part of the plant's or microbe's biomass. CO2 is a greenhouse gas that absorbs infrared radiation and traps heat in
Earth's atmosphere.
CO2fertilization CO2 fertilization Increase in plant growth due to a higher­than-normal carbon dioxide concentration in the environment.
Calvincycle Calvin cycle A series of photosynthetic chemical reactions that do not require light to occur. The Calvin cycle uses energy produced by light-dependent reactions of photosynthesis to incorporate carbon from carbon dioxide into organic compounds used to make sugars, starches, and other biological molecules.
carbonallocation Carbon allocation See carbon partitioning.
carboncycle Carbon cycle The complex carbon flows and transformations among major Earth system components (atmosphere, oceans, and terrestrial systems). The global flow of carbon from one reservoir (carbon sink) to another. Each carbon exchange among reservoirs is mediated by a variety of physical, biogeochemical, and human activities.
carbondioxide Carbon dioxide Gas that is an important part of the global carbon cycle. CO2 is emitted from a variety of processes (e.g., cellular respiration, biomass decomposition, fossil fuel use) and taken up primarily by the photosynthesis of plants and microorganisms. CO2 is a greenhouse gas that absorbs infrared radiation and traps heat in the Earth's atmosphere.
carbonfixation Carbon fixation Conversion of inorganic carbon dioxide to organic compounds by photosynthesis.
carbonflux Carbon flux Rate of carbon movement as it flows from one carbon reservoir to another in the global carbon cycle. For the global carbon budget, carbon flux is usually expressed in gigatons of carbon per year (GT C/yr).
carbonpartitioning Carbon partitioning Partitioning to different parts of a plant (e.g., leaf, stem, root, and seed) versus carbon allocation (partitioning between biomass and respiration).
carbonsequestration Carbon sequestration Biological or physical process that captures carbon dioxide and converts it into inert, long-lived, carbon-containing materials.
carbonsink Carbon sink A pool (reservoir) that absorbs or takes up released carbon from another part of the carbon cycle. For example, if the net exchange between the biosphere and the atmosphere
is toward the atmosphere, the biosphere is the source, and the
atmosphere is the sink.
carbonsource Carbon source A pool (reservoir) that releases carbon to another part of the carbon cycle.
carbonuseefficiencyCUE Carbon use efficiency (CUE) Ratio of net primary productivity to gross primary productivity.
carrier Carrier An individual who possesses an unexpressed, recessive trait.
cdnalibrary cDNA library A collection of DNA sequences that code for genes. The sequences are generated in the laboratory from mRNA sequences.
See also: messenger RNA
cell Cell The basic unit of any living organism that carries on the biochemical processes of life.
See also: genome, nucleus
cellulose Cellulose Linear polysaccharide polymer with many glucose monosaccharide units. Cellulose is the major component of plant cell walls and the most abundant biological material on Earth.
centimorgan Centimorgan (cM) A unit of measure of recombination frequency. One centimorgan is equal to a 1% chance that a marker at one genetic locus will be separated from a marker at a second locus due to crossing over in a single generation.
See also: megabase
centromere Centromere A specialized chromosome region to which spindle fibers attach during cell division.
chemoautotroph Chemoautotroph An organism that biochemically synthesizes its own organic materials from inorganic compounds using chemical energy.
chemostat Chemostat Apparatus for the continuous cultivation of bacteria. Chemostats keep bacterial cultures in an optimal growth state by continually adding media and removing old cells.
chimera Chimera (pl. chimaera) An organism that contains cells or tissues with a different genotype. These can be mutated cells of the host organism or cells from a different organism or species.
chimeraplasty Chimeraplasty An experimental targeted repair process in which a desirable sequence of DNA is combined with RNA to form a chimeraplast. These molecules bind selectively to the target DNA. Once bound, the chimeraplast activates a naturally occurring gene-correcting mechanism. Does not use viral or other conventional gene-delivery vectors.
See also: cloning vector
chlorophyll Chlorophyll A type of green pigment used to harness light energy in the chloroplasts of plants and other photosynthetic organisms.
chloroplast Chloroplast An organelle in the cells of green plants. It contains chlorophyll and functions in photosynthesis and protein synthesis.
chloroplastchromosome Chloroplast chromosome Circular DNA found in the photosynthesizing organelle (chloroplast) of plants instead of the cell nucleus where most genetic material is located.
chromatinimmunoprecipitationChIP Chromatin immunoprecipitation (ChIP) Method used to determine the location in a genome of DNA binding sites recognized by a particular protein of interest.
chromomere Chromomere One of the serially aligned beads or granules of a eukaryotic chromosome, resulting from local coiling of a continuous DNA thread.
chromosomaldeletion Chromosomal deletion The loss of part of a chromosome's DNA.
chromosomalinversion Chromosomal inversion Chromosome segments that have been turned 180 degrees. The gene sequence for the segment is reversed with respect to the rest of the chromosome.
chromosome Chromosome The self-replicating genetic structure of cells containing the cellular DNA that bears in its nucleotide sequence the linear array of genes. In prokaryotes, chromosomal DNA is circular, and the entire genome is carried on one chromosome. Eukaryotic genomes consist of a number of chromosomes whose DNA is associated with different kinds of proteins.
chromosomepainting Chromosome painting Attachment of certain fluorescent dyes to targeted parts of the chromosome.
chromosomeregionp Chromosome region p A designation for the short arm of a chromosome.
chromosomeregionq Chromosome region q A designation for the long arm of a chromosome.
climate Climate Average weather conditions over a time period, usually several decades. Climate is largely determined by local geographical features, latitude, altitude, land- and sea-masses, and atmospheric circulation patterns.
climatemodel Climate model Mathematical model used to understand, simulate, and predict climate trends by quantitatively analyzing interactions among Earth system components (e.g., land, ocean, atmosphere, and biosphere).
clone Clone An exact copy made of biological material such as a DNA segment (e.g., a gene or other region), a whole cell, or a complete organism.
clonebank Clone bank See: genomic library
cloning Cloning Using specialized DNA technology to produce multiple, exact copies of a single gene or other segment of DNA to obtain enough material for further study. The resulting cloned (copied) collections of DNA molecules are called clone libraries. A second type of cloning exploits the natural process of cell division to make many copies of an entire cell. The genetic makeup of these cloned cells, called a cell line, is identical to the original cell.
See also: cloning vector
cloningvector Cloning vector DNA molecule originating from a virus, a plasmid, or the cell of a higher organism into which another DNA fragment of appropriate size can be integrated without loss of the vector's capacity for self-replication; vectors introduce foreign DNA into host cells, where the DNA can be reproduced in large quantities. Examples are plasmids, cosmids, and yeast artificial chromosomes; vectors are often recombinant molecules containing DNA sequences from several sources.
coccolithophore Coccolithophore A type of single-celled marine algae distinguished by its production of intricate, microscopic shells that are aggregates of calcium carbonate discs called coccoliths.
code Code See: genetic code
codominance Codominance Situation in which two different alleles for a genetic trait are both expressed.
See also: recessive gene
codon Codon See: genetic code
cofactor Cofactor An organic or inorganic substance required by an enzyme to function.
coisogenicorcongenic Coisogenic or congenic Nearly identical strains of an organism; they vary at only a single locus.
community Community All the different species of organisms living together and interacting in a particular environment.
comparativegenomics Comparative genomics The study of genetics by comparisons with other organisms.
complementarydna Complementary DNA (cDNA) DNA that is synthesized in the laboratory from a messenger RNA template.
complementaryRNAcRNA Complementary RNA (cRNA) Synthetic transcripts of a specific DNA molecule or fragment made by an in vitro transcription system.
complementarysequence Complementary sequence Nucleic acid base sequence that can form a double-stranded structure with another DNA fragment by following base-pairing rules (A pairs with T and C with G). The complementary sequence to GTAC for example, is CATG.
completegenomesequencefinisheddnasequence Complete Genome Sequence High-quality, low error, gap-free DNA sequence of an entire genome of an organism.
complextrait Complex trait Trait that has a genetic component that does not follow strict Mendelian inheritance. May involve the interaction of two or more genes or gene-environment interactions.
See also: Mendelian inheritance, additive genetic effects
computationalbiology Computational biology Development and application of data-analysis and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological systems.
See also: bioinformatics
conservedhypotheticalproteins Conserved hypothetical proteins The (often large) fraction of genes in sequenced genomes encoding proteins that are found in organisms from several phylogenetic lineages but have not been functionally characterized and described at the protein chemical level. These structures may represent up to half of the potential protein coding regions of a genome.
conservedsequence Conserved sequence A base sequence in a DNA molecule (or an amino acid sequence in a protein) that has remained essentially unchanged throughout evolution.
constitutiveablation Constitutive ablation Gene expression that results in cell death.
contig Contig Group of cloned (copied) pieces of DNA representing overlapping regions of a particular chromosome.
contigmap Contig map A map depicting the relative order of a linked library of overlapping clones representing a complete chromosomal segment.
copepod Copepod A type of microscopic marine and freshwater crustacean that has an elongated body and a forked tail.
cosmid Cosmid Artificially constructed cloning vector containing the cos gene of phage lambda. Cosmids can be packaged in lambda phage particles for infection into E. coli; this permits cloning of larger DNA fragments (up to 45kb) than can be introduced into bacterial hosts in plasmid vectors.
crenarchaea Crenarchaea A phylum of archaea distinguished from other phyla based on rRNA sequence. Crenarchaea are the most abundant type of marine archaea.
crossingover Crossing over The breaking during meiosis of one maternal and one paternal chromosome, the exchange of corresponding sections of DNA, and the rejoining of the chromosomes. This process can result in an exchange of alleles between chromosomes.
See also: recombination
cyanobacteria Cyanobacteria Division of photosynthetic bacteria found in many environments, including oceans, fresh water, and soils. Cyanobacteria contain chlorophyll a and other photosynthetic pigments in an intracellular system of membranes called thylakoids. Many cyanobacterial species also are capable of nitrogen fixation.
cytogenetics Cytogenetics The study of the physical appearance of chromosomes.
See also: karyotype
cytologicalband Cytological band An area of the chromosome that stains differently from areas around it.
See also: cytological map
cytologicalmap Cytological map A type of chromosome map whereby genes are located on the basis of cytological findings obtained with the aid of chromosome mutations.
cytoplasm Cytoplasm All cellular contents surrounding the nucleus of a membrane-bound eukaryotic cell.
cytoplasmic(uniparental)inheritance Cytoplasmic (uniparental) inheritance See: cytoplasmic trait
cytoplasmictrait Cytoplasmic trait A genetic characteristic in which the genes are found outside the nucleus, in chloroplasts or mitochondria. Results in offspring inheriting genetic material from only one parent.
cytosine Cytosine (C) A nitrogenous base, one member of the base pair GC (guanine and cytosine) in DNA.
See also: base pair, nucleotide
datawarehouse Data warehouse A collection of databases, data tables, and mechanisms to access the data on a single subject.
deletion Deletion A loss of part of the DNA from a chromosome; can lead to a disease or abnormality.
See also: chromosome, mutation
deletionmap Deletion map A description of a specific chromosome that uses defined mutations --specific deleted areas in the genome-- as 'biochemical signposts,' or markers for specific areas.
denitrification Denitrification Anaerobic conversion of nitrate or nitrite to nitrogen gas (N2) by denitrifying bacteria. A small portion of nitrate or nitrite may be converted to nitrous oxide (N2O), a potent greenhouse gas.
deoxyribonucleotide Deoxyribonucleotide See: nucleotide
deoxyribose Deoxyribose A type of sugar that is one component of DNA (deoxyribonucleic acid).
desorption Desorption Removal of a substance in the reverse of absorption or adsorption.
detritus Detritus Remnants of biological material.
diatom Diatom Type of microscopic, photosynthetic algae known for its intricately designed, silica-containing shell. Thousands of diatom species are known; most are unicellular, but some form colonies. Diatoms are responsible for a large portion of photosynthetic carbon assimilation in marine and freshwater environments.
dinoflagellate Dinoflagellate Any of a group of eukaryotic microorganisms containing both plant-like and animal-like species that lives in marine and freshwater environments. These unicellular microorganisms use a pair of dissimilar cellular appendages called flagella for motility.
diploid Diploid A full set of genetic material consisting of paired chromosomes, one from each parental set.
See also: haploid
directedevolution Directed evolution A laboratory process used on isolated molecules or microbes to cause mutations and identify subsequent adaptations to novel environments.
directedmutagenesis Directed mutagenesis Alteration of DNA at a specific site and its reinsertion into an organism to study any effects of the change.
directedsequencing Directed sequencing Successively sequencing DNA from adjacent stretches of chromosome.
disturbance Disturbance Any abrupt event that drastically changes ecosystem characteristics such as population diversity, behavior, or climate response.
DNAdeoxyribonucleicacidDNA DNA (deoxyribonucleic acid) Molecule that encodes genetic information. DNA is a double-stranded molecule held together by weak bonds between base pairs of nucleotides. The four nucleotides in DNA contain the bases adenine (A), guanine (G), cytosine (C), and thymine (T). A pairs with T and C pairs with G.
DNAannotation DNA annotation
See genome annotation
DNAassembly DNA assembly See genome assembly
dnaprobe DNA probe See: probe
dnarepairgenes DNA repair genes Genes encoding proteins that correct errors in DNA sequencing.
dnareplication DNA replication The use of existing DNA as a template for the synthesis of new DNA strands.
dnasequence DNA sequence The relative order of base pairs, whether in a DNA fragment, gene, chromosome, or an entire genome.
See also: base sequence analysis, genome sequence
domain Domain A discrete portion of a protein with its own function. The combination of domains in a single protein determines its overall function.
dominant Dominant An allele that is almost always expressed, even if only one copy is present.
See also: gene, genome
doublehelix Double helix The twisted-ladder shape that two linear strands of DNA assume when complementary nucleotides on opposing strands bond together.
draftsequence Draft sequence A DNA sequence that, while incomplete, offers a virtual road map to many of the known genes. Draft sequence data are mostly in the form of large-sized base pair fragments whose approximate chromosomal locations are known.
See also: sequencing, complete genome sequence, working draft DNA sequence
dynamicglobalvegetationmodelDGVM Dynamic global vegetation model (DGVM) Biogeographical model used to study how general categories of plant functional types are established and respond to competition, disturbances, and other factors.
Earth System Model(ESM) Earth System Model (ESM) A type of complex, global model that combines physical climate models, global biological processes, and human activities.
ecophysiology Ecophysiology Study of the physiological functions of organisms as they pertain to their ecology or interactions with each other and their environment.
ecosystem Ecosystem Set of living organisms (plants, animals, fungi, and microorganisms) and the physical and chemical factors that make up a particular environment.
ectomycorrhizae Ectomycorrhizae A type of mycorrhizal fungus that surrounds a plant root tip but does not penetrate the cell walls of the root with its hyphae.
edaphic Edaphic Related to or determined by soil characteristics (e.g., soil texture, composition, drainage).
ElNino El Niño An irregular variation of ocean current that flows off the west coast of South America, carrying warm, low-salinity, nutrient- poor water to the south. El Niño events, which occur every 4 to 12 years, can cause die-offs of plankton and fish and unusual weather patterns by altering jet stream winds and storm tracks.
electronacceptor Electron acceptor Substance that gains electrons from another substance in an oxidation-reduction reaction.
electrondonor Electron donor Substance that loses electrons to another substance in an oxidation-reduction reaction.
electrophoresis Electrophoresis A method of separating large molecules (such as DNA fragments or proteins) from a mixture of similar molecules. An electric current is passed through a medium containing the mixture, and each kind of molecule travels through the medium at a different rate, depending on its electrical charge and size. Agarose and acrylamide gels are the media commonly used for electrophoresis of proteins and nucleic acids.
electroporation Electroporation A process using high-voltage current to make cell membranes permeable to allow the introduction of new DNA; commonly used in recombinant DNA technology.
See also: transfection
endomycorrhizae Endomycorrhizae A type of mycorrhizal fungus that surrounds a plant root tip and uses its hyphae to penetrate the cell walls of the root. Endomycorrhizal fungi form vesicle-like structures at the root cell surface that enhance the transport of substances between a plant and fungus.
endonuclease Endonuclease See: restriction enzyme
endophyte Endophyte Any organism (usually a fungus or microbe) that lives inside another organism and establishes a parasitic or mutualistic relationship with its host.
entisols Entisols Undifferentiated soils of recent origin found in river valleys and deltas.
enzyme Enzyme A protein that acts as a catalyst, speeding the rate at which a biochemical reaction proceeds but not altering the direction or nature of the reaction.
epigenome Epigenome Set of chemical compounds that modify, or mark, the genome in a way that tells it what to do, where to do it, and when to do it. The marks, which are not part of the DNA itself, can be passed on from cell to cell as cells divide, and from one generation to the next.
epigenomics Epigenomics Study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. Epigenetic modifications are reversible modifications on a cell's DNA or histones that affect gene expression without altering the DNA sequence.
epiphyte Epiphyte Any organism that grows upon or attaches to a living plant for physical support but not for nutrients.
epistasis Epistasis Phenomenon where the effects of one gene are modified by one or several other genes. The gene whose phenotype is expressed is called epistatic, while the phenotype altered or suppressed is called hypostatic.
escherichiacoli Escherichia coli Common bacterium that has been studied intensively by geneticists because of its small genome size, normal lack of pathogenicity, and ease of growth in the laboratory.
eukaryote Eukaryote Single-celled or multicellular organism (e.g., plant, animal, or fungi) with a cellular structure that includes a membrane-bound, structurally discrete nucleus and other well-developed subcellular compartments.
See also: prokaryote
euphoticzone Euphotic zone The layer of a body of water that receives sufficient sunlight for photosynthesis. The depth of this layer, which is about 80 m, is determined by the water's extinction coefficient, its cloudiness, and the sunlight's angle of incidence.
evolutionarilyconserved Evolutionarily conserved See: conserved sequence
exogenousdna Exogenous DNA DNA originating outside an organism that has been introduced into the organism.
exon Exon The protein-coding DNA sequence of a gene.
See also: intron
exonuclease Exonuclease An enzyme that cleaves nucleotides sequentially from free ends of a linear nucleic acid substrate.
expressedgene Expressed gene See: gene expression
expressedsequencetag Expressed sequence tag (EST) A short strand of DNA that is a part of a cDNA molecule and can act as identifier of a gene. Used in locating and mapping genes.
expressionquantitativetraitlocuseQTL Expression quantitative trait locus (eQTL) Genomic locus that regulates expression levels of mRNAs or proteins.
See also: quantitative trait locus
extremophile Extremophile An organism that can survive in physically or chemically extreme conditions that are not livable to most other organisms.
exudates Exudates See root exudate.
feedback Feedback An interaction mechanism between processes in the Earth system that occurs when the result of an initial process triggers changes in a second process that in turn influences the initial one. A positive feedback intensifies the original process, and a negative feedback reduces it.
flowcytometry Flow cytometry Analysis of biological material by detection of the light-absorbing or fluorescing properties of cells or subcellular fractions (i.e., chromosomes) passing in a narrow stream through a laser beam. An absorbance or fluorescence profile of the sample is produced. Automated sorting devices, used to fractionate samples, sort successive droplets of the analyzed stream into different fractions depending on the fluorescence emitted by each droplet. Also known as flow sorting.
flowkaryotyping Flow karyotyping Use of flow cytometry to analyze and separate chromosomes according to their DNA content.
fluorescenceinsituhybridization Fluorescence in situ hybridization (FISH) A physical mapping approach that uses fluorescein tags to detect hybridization of probes with metaphase chromosomes and with the less-condensed somatic interphase chromatin.
fullgenesequence Full gene sequence The complete order of bases in a gene. This order determines which protein a gene will produce.
functionalannotation Functional annotation Process of attaching biological information (e.g., biochemical function, biological function, involved regulation and interactions, and expression) to genomic elements.
See also: genome annotation
functionalgenomics Functional genomics Study of sequencing data to describe gene (and protein) functions and interactions. Unlike genomics, functional genomics focuses on dynamic aspects such as gene transcription, translation, and protein-protein interactions, as opposed to the static aspects of genomic information such as DNA sequence or structures.
gaschromatography Gas chromatography An automated method for separating a substance into its components. The substance is volatilized and carried by a stream of gas through a column containing an inert solid or liquid matrix that separates each component before reaching a detector device.
gc-richarea GC-rich area Many DNA sequences carry long stretches of repeated G and C which often indicate a gene-rich region.
gelelectrophoresis Gel electrophoresis See: electrophoresis
gelisols Gelisols Cold surface soils with underlying permafrost.
gene Gene Fundamental physical and functional unit of heredity. A gene is an ordered sequence of nucleotides, located in a particular position on a particular chromosome, that encodes a specific functional product (i.e., a protein or RNA molecule). Multiple variants (see allele) can exist in a population.
geneamplification Gene amplification Repeated copying of a piece of DNA.
See also: gene
genechiptechnology Gene chip technology Development of cDNA microarrays from a large number of genes. Used to monitor and measure changes in gene expression for each gene represented on the chip.
geneexpression Gene expression Process by which a gene's coded information is converted into structures present and operating in the cell. Expressed genes include those transcribed into messenger RNA (mRNA) and then translated into proteins, as well as those transcribed into RNA but not translated into proteins [e.g., transfer (tRNA) and ribosomal RNA (rRNA)].
genefamily Gene family Group of closely related genes that make similar products.
genefunction Gene function Biochemical reaction, protein-protein interaction, metabolic or signaling pathway association, cellular localization, phenotype, and changes in protein function that are mediated by shifts in protein structure.
genelibrary Gene library See: genomic library
genemapping Gene mapping Determination of the relative positions of genes on a DNA molecule (chromosome or plasmid) and of the distance, in linkage units or physical units, between them.
genepool Gene pool All the variations of genes in a species.
See also: allele, gene, polymorphism
geneprediction Gene prediction Predictions of possible genes made by a computer program based on how well a stretch of DNA sequence matches known gene sequences
geneproduct Gene product Biochemical material, either RNA or protein, resulting from expression of a gene. The amount of gene product is used to measure a gene's level of expression (transcription).
genera Genera A taxonomic category of organisms that ranks between family and species. Genera (singular: genus) for higher organisms generally consist of species with similar characteristics.
general circulation model(GCM) General circulation model (GCM) A class of computer- driven models (sometimes called global circulation models) that provide weather forecasts and climate projections. GCMs integrate a variety of fluid dynamical, chemical, and biological equations that represent processes in Earth system components
(e.g., land, ocean, atmosphere, and biosphere).
generegulatorynetwork Gene regulatory network Intracellular network of regulatory proteins that control the expression of gene subsets involved in particular cellular functions. A simple network would consist of one or more input signaling pathways, regulatory proteins that integrate the input signals, several target genes (in bacteria a target operon), and the RNA and proteins produced from those target genes.
genetransfer Gene transfer Incorporation of new DNA into and organism's cells, usually by a vector such as a modified virus.
See also: mutation, vector
geneticcode Genetic code The sequence of nucleotides, coded in triplets (codons) along the mRNA, that determines the sequence of amino acids in protein synthesis. A gene's DNA sequence can be used to predict the mRNA sequence, and the genetic code can in turn be used to predict the amino acid sequence.
geneticengineering Genetic engineering Altering the genetic material of cells or organisms to enable them to make new substances or perform new functions.
geneticengineeringtechnology Genetic engineering technology See: recombinant DNA technology
geneticinformatics Genetic informatics See: bioinformatics
geneticmap Genetic map See: linkage map
geneticmarker Genetic marker A gene or other identifiable portion of DNA whose inheritance can be followed.
See also: chromosome, DNA, gene, inherit
geneticmaterial Genetic material See: genome
geneticmosaic Genetic mosaic An organism in which different cells contain different genetic sequence. This can be the result of a mutation during development or fusion of embryos at an early developmental stage.
genetics Genetics The study of inheritance patterns of specific traits.
genome Genome All the genetic material in the chromosomes of a particular organism. Most prokaryotes package their entire genome into a single chromosome, while eukaryotes have different numbers of chromosomes. Genome size generally is given as total number of base pairs.
genomeannotation Genome annotation Process of identifying elements in the genome and attaching biological information to these elements. Automatic annotation tools perform this process by computer analysis, as opposed to manual annotation (i.e., curation), which involves human expertise. Ideally, these approaches co-exist and complement each other in the same annotation pipeline.
See also: functional annotation, structural annotation
genomeassembly Genome assembly Process of taking a large number of short DNA sequences and putting them back together to create a representation of the original chromosomes from which the DNA originated. In a shotgun sequencing project, all the DNA from a source is first fractured into millions of small pieces. These pieces are then "read" by automated sequencing machines, which can read up to 1,000 nucleotides or bases at a time. A genome assembly algorithm works by taking all the pieces and aligning them to one another, and detecting all places where two of the short sequences, or reads, overlap. These overlapping reads can be merged, and the process continues.
genomeengineering Genome engineering Techniques for the targeted, specific modification of the genetic information (or genome) of living organisms.
genomeproject Genome project Research and technology-development effort aimed at mapping and sequencing the genome of organisms.
genomiclibrary Genomic library A collection of clones made from a set of randomly generated overlapping DNA fragments that represent the entire genome of an organism.
See also: library, arrayed library
genomesequence Genome sequence Order of nucleotides or bases within DNA molecules that make up an organism's entire genome. The four bases are adenine, guanine, cytosine, and thymine, represented as A, G, C, and T.
genomewideassociationstudyGWAS Genome-wide association study (GWAS) Examination of many common genetic variants in different organisms to see if any variant is statistically associated with a trait. GWAS are used to identify candidate genes or sequence variants that may link to a condition or property of interest.
genomics Genomics The study of genes and their function.
genotype Genotype An organism's genetic constitution, as distinguished from its physical characteristics (phenotype).
gigaton(GT) Gigaton (GT) One billion metric tons; a metric ton is a unit of mass equal to 1000 kg (about 2200 lb).
greenhousegas Greenhouse gas Heat-trapping gas such as carbon dioxide, methane, nitrous oxide, or dimethyl sulfide released into the atmosphere as a result of human activities (primarily fossil fuel combustion) and natural processes (e.g., cellular respiration, biomass decomposition, volcanic activity).
grossprimaryproductivity(GPP) Gross primary productivity (GPP) Total amount of organic matter created by photosynthesis over a defined time period (total product of photosynthesis).
guanine Guanine (G) A nitrogenous base, one member of the base pair GC (guanine and cytosine) in DNA.
See also: base pair, nucleotide
haploid Haploid A single set of chromosomes (half the full set of genetic material) present in the egg and pollen cells of plants.
See also: diploid
haplotype Haplotype A segment of DNA containing closely linked gene variations that are inherited as a unit.
hemicellulose Hemicellulose Any of several polysaccharides (e.g., xylans, mannans, and galactans) that cross link and surround cellulose fibers in plant cell walls. Where cellulose is regular in organization and consequently strong, hemicelluloses are more commonly random in structure and more easily hydrolyzed.
heterotroph Heterotroph Organism that obtains organic carbon by consuming other organisms or the products of other organisms.
heterozygosity Heterozygosity The presence of different alleles at one or more loci on homologous chromosomes.
heterozygote Heterozygote See: heterozygosity
heterozygous Heterozygous Having two different alleles for a single trait, or having two different alleles at a single gene or genetic locus. An allele can be dominant, co-dominant, or recessive.
hexose Hexose A type of sugar molecule that contains six carbon atoms (e.g., glucose, fructose).
highlyconservedsequence Highly conserved sequence DNA sequence that is very similar across several different types of organisms.
See also: gene, mutation
highthroughput High throughput Done on a massive, automated scale.
high-throughputsequencing High-throughput sequencing A fast method of determining the order of bases in DNA.
See also: sequencing
histone Histone Protein that provides structural support to a chromosome. For very long DNA molecules to fit into the cell nucleus, they wrap around complexes of histone proteins, giving the chromosome a more compact shape. Some histones variants are associated with the regulation of gene expression.
histosols Histosols Poorly drained soils in swamps and bogs that contain more than 20% organic matter.
homeobox Homeobox A short stretch of nucleotides whose base sequence is virtually identical in all the genes that contain it. Homeoboxes have been found in many organisms. In the fruit fly, a homeobox appears to determine when particular groups of genes are expressed during development.
homeostasis Homeostasis Tendency of an organism or a cell to maintain its internal conditions regardless of external changing conditions.
homolog Homolog A member of a chromosome pair in diploid organisms or a gene that has the same origin and functions in two or more species.
homologouschromosome Homologous chromosome Chromosome containing the same linear gene sequences as another, each derived from one parent.
homologousrecombination Homologous recombination Swapping of DNA fragments between paired chromosomes.
homology Homology Similarity in DNA sequence or structure based on descent from a common ancestor.
homozygote Homozygote An organism that has two identical alleles of a gene.
See also: heterozygote
homozygous Homozygous See: homozygote
horizontalgenetransfer Horizontal gene transfer Exchange of genetic material between two different organisms (typically different species of prokaryotes). This process gives prokaryotes the ability to obtain novel functionalities or cause dramatic changes in community structure over relatively short periods of time.
humus Humus Long-lived mixture of organic compounds derived from the microbial decomposition of plant and animal matter in soils.
hybrid Hybrid The offspring of genetically different parents.
See also: heterozygote
hybridization Hybridization The process of joining two complementary strands of DNA or one each of DNA and RNA to form a double-stranded molecule.
hydrometeoric Hydrometeoric Relating to atmospheric phenomena that depend on water vapor.
hydrophilic Hydrophilic Having the ability to readily interact with water.
hydrophobic Hydrophobic Incapable of interacting with water.
hydrotropism Hydrotropism Ability of a plant to sense and grow toward water.
hyphae Hyphae Branching, threadlike filamentous cells of a fungus.
insituhybridization In situ hybridization Use of a DNA or RNA probe to detect the presence of the complementary DNA sequence in cloned bacterial or cultured eukaryotic cells.
interactionnetwork Interaction network Diagram that shows numerous molecular interactions of a cell. Each point or node on the diagram represents a molecule (typically a protein), and each line connecting two nodes indicates that two molecules are capable of interacting.
interactome Interactome Molecular interactions of a cell, typically used to describe all protein-protein interactions or those between proteins and other molecules.
insilico In silico Using computers to simulate and investigate natural processes.
insitu In situ In a natural environment.
invitro In vitro Outside of a living organism.
invivo In vivo Within a living organism.
inceptisols Inceptisols Variable soils with horizon development in early stages.
independentassortment Independent assortment During meiosis each of the two copies of a gene is distributed to the germ cells independently of the distribution of other genes.
See also: linkage
informatics Informatics See: bioinformatics
inherit Inherit In genetics, to receive genetic material from parents through biological processes.
inherited Inherited See: inherit
insertion Insertion A chromosome abnormality in which a piece of DNA is incorporated into a gene and thereby disrupts the gene's normal function.
See also: chromosome, DNA, gene, mutation
insertionalmutation Insertional mutation See: insertion
intellectualpropertyrights Intellectual property rights Patents, copyrights, and trademarks.
See also: patent
interactionnetwork Interaction network Diagram that shows numerous molecular interactions of a cell. Each point or node on the diagram represents a molecule (typically a protein), and each line connecting two nodes indicates that two molecules are capable of interacting.
interactome Interactome Molecular interactions of a cell, typically used to describe all protein-protein interactions or those between proteins and other molecules.
interference Interference One crossover event inhibits the chances of another crossover event. Also known as positive interference. Negative interference increases the chance of a second crossover.
See also: crossing over
interphase Interphase The period in the cell cycle when DNA is replicated in the nucleus; followed by mitosis.
intron Intron DNA sequence that interrupts the protein-coding sequence of a gene; an intron is transcribed into RNA but is cut out of the message before it is translated into protein.
See also: exon
isoenzyme Isoenzyme An enzyme performing the same function as another enzyme but having a different set of amino acids. The two enzymes may function at different speeds.
isotope Isotope Atom that has the same number of protons as another atom but a different number of neutrons and hence atomic mass. For example, 13C is an isotope of carbon that has one more neutron than the most common isotope of carbon, 12C.
junkdna Junk DNA Stretches of DNA that do not code for genes; most of the genome consists of so-called junk DNA which may have regulatory and other functions. Also called non-coding DNA.
karyotype Karyotype A photomicrograph of individual chromosomes arranged in a standard format showing the number, size, and shape of each chromosome type; used in low-resolution physical mapping.
kilobase Kilobase (kb) Unit of length for DNA fragments equal to 1000 nucleotides.
knockout Knockout Deactivation of specific genes; used in laboratory organisms to study gene function.
See also: gene, locus
LaNina La Niña An irregular variation of ocean current that flows off the west coast of South America, carrying cool, nutrient-rich water to the surface. La Niña typically follows El Niño events, which occur every 4 to 12 years.
lateralgenetransfer Lateral gene transfer Exchange of genetic material between two different organisms (typically different species of prokaryotes). This process gives prokaryotes the ability to obtain novel functionalities or cause dramatic changes in community structure over relatively short periods of time.
library Library An unordered collection of clones (i.e., cloned DNA from a particular organism) whose relationship to each other can be established by physical mapping.
See also: genomic library, arrayed library
lignin Lignin Complex, insoluble polymer whose structure, while not well understood, gives strength and rigidity to cellulose fibers in the cell walls of woody plants. Lignin makes up a significant portion of the mass of dry wood and, after cellulose, is the second most abundant form of organic carbon in the biosphere.
linkage Linkage The proximity of two or more markers (e.g., genes, RFLP markers) on a chromosome; the closer the markers, the lower the probability that they will be separated during DNA repair or replication processes (binary fission in prokaryotes, mitosis or meiosis in eukaryotes), and hence the greater the probability that they will be inherited together.
linkagedisequilibrium Linkage disequilibrium Where alleles occur together more often than can be accounted for by chance. Indicates that the two alleles are physically close on the DNA strand.
See also: Mendelian inheritance
linkagemap Linkage map A map of the relative positions of genetic loci on a chromosome, determined on the basis of how often the loci are inherited together. Distance is measured in centimorgans (cM).
liquidchromatography Liquid chromatography An automated method used to separate, identify, and quantify the components of a liquid solution.
A sample is carried by a mobile liquid phase through a column
packed with solid particles that separates each component before
reaching a detector device.
localize Localize Determination of the original position (locus) of a gene or other marker on a chromosome.
loci locus Loci Chromosomal locations of genes or genetic markers. (singular: locus)
long-rangerestrictionmapping Long-Range Restriction Mapping Restriction enzymes are proteins that cut DNA at precise locations. Restriction maps depict the chromosomal positions of restriction-enzyme cutting sites. These are used as biochemical "signposts," or markers of specific areas along the chromosomes. The map will detail the positions where the DNA molecule is cut by particular restriction enzymes.
macroaggregates Macroaggregates Large (greater than 250 micrometers in size) mineral-organic matter complexes in soils that physically protect organic matter from degradation.
macrorestrictionmap Macrorestriction map Map depicting the order of and distance between sites at which restriction enzymes cleave chromosomes.
mapping Mapping See: gene mapping, linkage map, physical map
mappingpopulation Mapping population The group of related organisms used in constructing a genetic map.
marinesnow Marine snow Aggregates of mostly organic materials that sink to the ocean floor from the photosynthetically active surface layers.
marker Marker See: genetic marker
massspectrometry Mass spectrometry Method involving specialized instruments for measuring the mass and abundance of molecules in a mixture and identifying mixture components by mass and charge.
megabase Megabase (Mb) Unit of length for DNA fragments equal to 1 million nucleotides and roughly equal to 1 cM.
See also: centimorgan
meiosis Meiosis The process of two consecutive cell divisions in the diploid progenitors of sex cells. Meiosis results in four rather than two daughter cells, each with a haploid set of chromosomes.
See also: mitosis
membrane Membrane Semipermeable biological barrier consisting of lipids, proteins, and small amounts of carbohydrate. Membranes control the flow of chemical substances (e.g., nutrients, protons, ions, and wastes) in and out of cells or cellular compartments. They also serve as structural supports for systems of membrane- embedded proteins that mediate important biological processes such as photosynthesis and cellular respiration.
mendelianinheritance Mendelian inheritance One method in which genetic traits are passed from parents to offspring. Named for Gregor Mendel, who first studied and recognized the existence of genes and this method of inheritance.
See also: recessive gene
mesofauna Mesofauna Any animal of intermediate size (e.g., insects, earthworms).
mesophyll Mesophyll Internal, irregularly-shaped, photosynthetic tissue within a leaf.
messengerrna Messenger RNA (mRNA) RNA that serves as a template for protein synthesis.
See also: genetic code, transcription, translation
metabolicengineering Metabolic engineering Optimizing genetic and regulatory processes within cells to increase the cells' production of a certain substance.
metabolicfluxanalysisMFA Metabolic flux analysis (MFA) Method for measuring all the metabolic fluxes of an organism's central metabolism; 13C-labeled substrate is taken up by an organism, and the distribution of 13C throughout the metabolic network enables the quantification of labeled metabolite pools.
metabolism Metabolism Collection of all biochemical reactions that an organism uses to obtain the energy and materials it needs to sustain life. An organism uses energy and common biochemical intermediates released from the breakdown of nutrients to drive the synthesis of biological molecules.
metabolites Metabolites Small molecules (<500 Da) that are the substrates, intermediates, and products of enzyme-catalyzed metabolic reactions.
metabolomics Metabolomics Type of global molecular analysis that involves identifying and quantifying the metabolome-all metabolites present in a cell at a given time.
metadata Metadata Data that describe specific characteristics and usage aspects (e.g., what data are about, when and how data were created, who can access the data, and available formats) of raw data generated from different analyses.
metagenome Metagenome Genetic material recovered directly from environmental samples.
metagenomics Metagenomics Study of the collective DNA isolated directly from a community of organisms living in a particular environment.
metaomics Metaomics High-throughput, global analysis of DNA, RNA, proteins, or metabolites isolated directly from a community of organisms living in a particular environment.
metaphase Metaphase A stage in mitosis or meiosis during which the chromosomes are aligned along the equatorial plane of the cell.
metaproteomics Metaproteomics High-throughput, global analysis of proteins isolated directly from a community of organisms living in a particular environment. Metaproteomics can reveal which genes are actively translated into functional proteins by a community.
metatranscriptome Metatranscriptome Transcriptome of a group of interacting organisms or species.
metatranscriptomics Metatranscriptomics High-throughput, global analysis of RNA isolated directly from a community of organisms living in a particular environment. Metatranscriptomics can reveal which genes are actively expressed by a community.
methaneclathrates Methane clathrates Ice crystals that contain large amounts of methane. Massive quantities of methane clathrates have been found under sediments in the ocean floor.
microaggregates Microaggregates Small (50-250 micrometers in size) mineral-organic matter complexes in soils that physically protect organic matter from degradation.
microarray Microarray Analytical technique used to measure the mRNA abundance (gene expression) of thousands of genes in one experiment. The most common type of microarray is a glass slide onto which DNA fragments are chemically attached in an ordered pattern. As fluorescently labeled nucleic acids from a sample are applied to the microarray, they bind the immobilized DNA fragments and generate a fluorescent signal indicating the relative abundance of each nucleic acid in the sample.
microbialgenetics Microbial genetics The study of genes and gene function in bacteria, archaea, and other microorganisms. Often used in research in the fields of bioremediation, alternative energy, and disease prevention.
See also: biotechnology, bioremediation
microbiome Microbiome A community of microorganisms that inhabit a particular environment. For example, a plant microbiome includes all the microorganisms that colonize a plant's surfaces and internal passages.
microfluidics Microfluidics Technology platforms that deal with the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale.
microinjection Microinjection A technique for introducing a solution of DNA into a cell using a fine microcapillary pipet.
micronuclei Micronuclei Chromosome fragments that are not incorporated into the nucleus at cell division.
microorganism Microorganism Any unicellular prokaryotic or eukaryotic organism, sometimes called a microbe.
mitochondrialdna Mitochondrial DNA The genetic material found in mitochondria, the organelles that generate energy for the cell. Not inherited in the same fashion as nucleic DNA.
See also: cell, DNA, genome, nucleus
mitosis Mitosis The process of nuclear division in cells that produces daughter cells that are genetically identical to each other and to the parent cell.
See also: meiosis
mixotrophic Mixotrophic Having both autotrophic and heterotrophic capabilities.
model Model Mathematical or other (e.g., engineering) representation used in computer simulations to calculate the evolving state of dynamic systems.
modelecosystem Model ecosystem A specific type of ecosystem that is widely studied in great detail by a community of researchers to provide insights into the processes controlling the behavior of other ecosystems.
modelorganism Model organism Organism studied widely by a community of researchers. Biological understanding obtained from model-organism research is used to provide insights into the biological mechanisms of other organisms. Model organisms include the bacteria Escherichia coli, the yeast Saccharomyces cerevisiae, and the mustard weed Arabidopsis thaliana.
modeling Modeling Use of statistical and computational techniques to create working computer-based models of biological phenomena that can help to formulate hypotheses for experimentation and predict outcomes of research.
molecularbiology Molecular biology The study of the structure, function, and makeup of biologically important molecules.
moleculargenetics Molecular genetics The study of macromolecules important in biological inheritance.
molecularmachine Molecular machine Highly organized assembly of proteins and other molecules that work together as a functional unit to carry out operational, structural, and regulatory activities in the cells.
mollisols Mollisols Grassland soils with a thick, dark organic-surface horizon.
multiplexing Multiplexing A laboratory approach that performs multiple sets of reactions in parallel (simultaneously); greatly increasing speed and throughput.
mutagen Mutagen An agent that causes a permanent genetic change in a cell. Does not include changes occurring during normal genetic recombination.
mutagenicity Mutagenicity The capacity of a chemical or physical agent to cause permanent genetic alterations.
mutation Mutation Any heritable change in DNA sequence.
See also: polymorphism
mycelium Mycelium Mass of hyphae that make up the body of a fungus.
mycorrhizae Mycorrhizae Fungi that establish symbiotic relationships with plant roots.
nano-SIMS Nano-SIMS Imaging technique that uses a nanoscale secondary ion mass spectrometer (nano-SIMS) and cells labeled with stable isotopes of carbon and/or nitrogen to identify areas of active growth and follow nutrient fluxes between cells.
netbiomeproductivity(NBP) Net biome productivity (NBP) Amount of organic carbon that remains in a biome after accounting for carbon losses or gains from disturbances such as fire, disease, and human land use.
netecosystemproductivity(NEP) Net ecosystem productivity (NEP) Amount of organic carbon (e.g., plant biomass, soil organic matter) that remains after respiration by photosynthetic organisms, heterotrophs, and decomposers.
netprimaryproductivity(NPP) Net primary productivity (NPP) Fraction of photosynthetically fixed energy that remains after accounting for cellular respiration. NPP also is defined as the total amount of photosynthetic biomass created annually.
nitrification Nitrification Transformation of ammonium ions to nitrate by nitrifying bacteria.
nitrogenase Nitrogenase Enzyme that catalyzes the conversion of atmospheric nitrogen (N2) to nitrate in nitrogen-fixing bacteria and archaea.
nitrogenfixation Nitrogen fixation Process carried out by certain species of bacteria and archaea in which atmospheric nitrogen (N2) is converted to organic nitrogen-containing compounds that can be used by other organisms.
nitrogenousbase Nitrogenous base A nitrogen-containing molecule having the chemical properties of a base. DNA contains the nitrogenous bases adenine (A), guanine (G), cytosine (C), and thymine (T).
See also: DNA
northernblot Northern blot A gel-based laboratory procedure that locates mRNA sequences on a gel that are complementary to a piece of DNA used as a probe.
See also: DNA, library
nuclearmagneticresonance(NMR) Nuclear magnetic resonance (NMR) Technique used to study molecular structure by analyzing the absorption of electromagnetic resonance at a specific frequency in atoms subjected to strong magnetic field.
nucleicacid Nucleic acid A large molecule composed of nucleotide subunits.
See also: DNA
nucleolarorganizingregion Nucleolar organizing region A part of the chromosome containing rRNA genes.
nucleotide Nucleotide A subunit of DNA or RNA consisting of a nitrogenous base (adenine, guanine, thymine, or cytosine in DNA; adenine, guanine, uracil, or cytosine in RNA), a phosphate molecule, and a sugar molecule (deoxyribose in DNA and ribose in RNA). Thousands of nucleotides are linked to form a DNA or RNA molecule.
See also: DNA, base pair, RNA
nucleus Nucleus The cellular organelle in eukaryotes that contains most of the genetic material.
oligo Oligo See: oligonucleotide
oligogenic Oligogenic A phenotypic trait produced by two or more genes working together.
oligonucleotide Oligonucleotide Short nucleic acid polymer, typically with 50 or fewer bases.
See also: nucleotide
oligotrophic Oligotrophic Term used to describe lakes or other bodies of water that lack nutrients and plant life and have high concentrations of dissolved oxygen.
omics 'omics Collective term for a range of new high-throughput biological research methods (e.g., transcriptomics, proteomics, and metabolomics) that systematically investigate entire networks of genes, proteins, and metabolites within cells.
openreadingframe Open reading frame (ORF) The sequence of DNA or RNA located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon).
operon Operon A set of genes transcribed under the control of an operator gene.
organelle Organelle Specialized subunit within a cell that has a specific function and is usually separately enclosed within its own lipid bilayer.
ortholog Ortholog Similar gene or gene segments appearing in the genomes of different species but resulting from speciation and mutation.
overlappingclones Overlapping clones See: genomic library
oxidation Oxidation Loss of one or more electrons from a chemical substance.
oxisols Oxisols Tropical soils rich in iron and aluminum oxides.
p1-derivedartificialchromosome P1-derived artificial chromosome (PAC) One type of vector used to clone DNA fragments (100- to 300-kb insert size; average, 150 kb) in Escherichia coli cells. Based on bacteriophage (a virus) P1 genome.
See also: cloning vector
patent Patent In genetics, conferring the right or title to genes, gene variations, or identifiable portions of sequenced genetic material to an individual or organization.
See also: gene
pathway Pathway Series of molecular interactions that occur in a specific sequence to carry out a particular cellular process (e.g., sense a signal from the environment, convert sunlight to chemical energy, break down or harvest energy from a carbohydrate, synthesize ATP, or construct a molecular machine).
pedigree Pedigree A family tree diagram that shows how a particular genetic trait has been inherited.
See also: inherit
pelagiczone Pelagic zone Open ocean that is not near the coast or ocean floor.
penetrance Penetrance The probability of a gene or genetic trait being expressed. "Complete" penetrance means the gene or genes for a trait are expressed in all the population who have the genes. "Incomplete" penetrance means the genetic trait is expressed in only part of the population. The percent penetrance also may change with the age range of the population.
peptide Peptide Two or more amino acids joined by a bond called a "peptide bond."
See also: polypeptide
perennial Perennial Plant that lives from year to year.
ph PH Scale used to specify acidity or alkalinity. The hydrogen ion (H+) concentration of a sample determines its pH (pH = -log10 [H+]); the higher the H+ concentration, the lower the pH. A solution with a pH value of 7 is neutral; less than 7 is acidic; and greater than 7 is alkaline or basic.
phage Phage A virus for which the natural host is a bacterial cell.
phenocopy Phenocopy A trait not caused by inheritance of a gene but appears to be identical to a genetic trait.
phenology Phenology Study of recurring biological phenomena.
phenomics Phenomics Collective study of multiple phenotypes (e.g., all phenotypes associated with a particular biological function).
phenotype Phenotype Physical characteristics of an organism.
phloem Phloem Vascular tissue that distributes sugars and nutrients throughout a plant.
photosynthate Photosynthate Organic carbon produced by photosynthesis.
photosynthesis Photosynthesis Process by which plants, algae, and certain types of prokaryotic organisms capture light energy and use it to drive the transfer of electrons from inorganic donors (e.g., water) to carbon dioxide to produce energy-rich carbohydrates.
photosystem Photosystem Large, membrane-bound molecular complex consisting of multiple proteins containing pigment molecules (e.g., chlorophylls) that absorb light at a particular wavelength and transfer the energy from the absorbed photon to a reaction center that initiates a series of electron-transport reactions.
phototroph Phototroph Organism capable of photosynthesis.
phylogenetics Phylogenetics Study of evolutionary relationships among groups of organisms (e.g., species, populations), based on their DNA sequences.
phylogenomics Phylogenomics Comparison and analysis of entire genomes, or large portions of genomes, to determine the relationship of the function of genes to their evolution.
phylogeny Phylogeny Evolutionary history that traces the development of a species or taxonomic group over time.
physicochemical Physicochemical Relating to both physical and chemical properties.
phytoplankton Phytoplankton Free-floating, microscopic photosynthetic organisms (e.g., algae, cyanobacteria, dinoflagellates found in the surface layers of marine and freshwater environments).
physicalmap Physical map A map of the locations of identifiable landmarks on DNA (e.g., restriction-enzyme cutting sites, genes), regardless of inheritance. Distance is measured in base pairs.
physiology Physiology Study of the functions of living organisms and the factors that influence those functions.
phytoplankton Phytoplankton Free-floating, microscopic photosynthetic organisms (e.g., algae, cyanobacteria, dinoflagellates) found in the surface layers of marine and freshwater environments.
phytosiderophores Phytosiderophores Chemical compounds released from the roots of certain plants (e.g., grasses) to sequester iron from the environment.
plasmid Plasmid Autonomously replicating extra-chromosomal circular DNA molecules, distinct from the normal bacterial genome and nonessential for cell survival under nonselective conditions. Some plasmids are capable of integrating into the host genome. A number of artificially constructed plasmids are used as cloning vectors.
pleiotropy Pleiotropy One gene that causes many different physical traits such as multiple disease symptoms.
pluripotency Pluripotency The potential of a cell to develop into more than one type of mature cell, depending on environment.
polymer Polymer A large molecule formed by the linking together of smaller subunit molecules.
polymerasechainreaction Polymerase chain reaction (PCR) A method for amplifying a DNA base sequence using a heat-stable polymerase and two 20-base primers, one complementary to the (+) strand at one end of the sequence to be amplified and one complementary to the (-) strand at the other end. Because the newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample.
polymerase,dnaorrna Polymerase, DNA or RNA Enzyme that catalyzes the synthesis of nucleic acids on preexisting nucleic acid templates, assembling RNA from ribonucleotides or DNA from deoxyribonucleotides.
polymorphism Polymorphism Occurs when two or more clearly different phenotypes exist in the same population of a species (i.e., the occurrence of more than one form or morph).
polypeptide Polypeptide A protein or part of a protein made of a chain of amino acids joined by a peptide bond.
polyploid Polyploid Cells and organisms that contain more than two paired (homologous) sets of chromosomes. Most eukaryotic species are diploid, meaning they have two sets of chromosomes-one set inherited from each parent. However, polyploidy is found in some organisms and is especially common in plants.
population Population Collection of organisms of the same species living together in a given area. A community comprises several different populations.
populationgenetics Population genetics Study of allele frequency distribution and change under the influence of the four main evolutionary processes: natural selection, genetic drift, mutation, and gene flow. Population genetics also encompasses the factors of recombination, population subdivision, and population structure and attempts to explain such phenomena as adaptation and speciation.
positionalcloning Positional cloning A technique used to identify genes, usually those that are associated with diseases, based on their location on a chromosome.
prematurechromosomecondensation Premature chromosome condensation (PCC) A method of studying chromosomes in the interphase stage of the cell cycle.
primaryproduction Primary production Synthesis and storage of organic molecules (biomass), starting with fixation of CO2 by photosynthesis, in plants and microorganisms.
primer Primer Short preexisting polynucleotide chain to which new deoxyribonucleotides can be added by DNA polymerase.
probe Probe Single-stranded DNA or RNA molecules of specific base sequence, labeled either radioactively or immunologically, that are used to detect the complementary base sequence by hybridization.
prokaryote Prokaryote Single-celled organism lacking a membrane-bound, structurally discrete nucleus and other subcellular compartments. Bacteria and archaea are prokaryotes.
See also: eukaryote
promoter Promoter A DNA site to which RNA polymerase will bind and initiate transcription.
protein Protein Large molecule composed of one or more chains of amino acids in a specific order; the order is determined by the base sequence of nucleotides in the gene that codes for the protein. Proteins maintain distinct cell structure, function, and regulation.
proteincomplex Protein complex Aggregate structure consisting of multiple protein molecules.
proteinexpression Protein expression Subcomponent of gene expression. It consists of the stages after DNA has been transcribed to mRNA. The mRNA is then translated into polypeptide chains, which are ultimately folded into proteins.
proteome Proteome Collection of proteins expressed by a cell at a particular time and under specific conditions.
proteomics Proteomics Large-scale analysis of the proteome to identify which proteins are expressed by an organism under certain conditions. Proteomics provides insights into protein function, modification, regulation, and interaction.
proteorhodopsin Proteorhodopsin Light-dependent proton pumps in marine bacteria.
protozoa Protozoa Single-celled, eukaryotic microorganisms that use cellular appendages called flagella to propel them through their environments.
pseudogene Pseudogene A sequence of DNA similar to a gene but nonfunctional; probably the remnant of a once-functional gene that accumulated mutations.
purine Purine A nitrogen-containing, double-ring, basic compound that occurs in nucleic acids. The purines in DNA and RNA are adenine and guanine.
See also: base pair
pyrimidine Pyrimidine A nitrogen-containing, single-ring, basic compound that occurs in nucleic acids. The pyrimidines in DNA are cytosine and thymine; in RNA, cytosine and uracil.
See also: base pair
quantitativetraitlocus Quantitative trait locus Stretch of DNA containing or linked to the genes that underlie a quantitative trait.
See also: expression quantitative trait locus
radioisotope Radioisotope Unstable isotope of an element that releases radiation as it decays to a stable form.
rare-cutterenzyme Rare-cutter enzyme See: restriction-enzyme cutting site
recessivegene Recessive gene A gene which will be expressed only if there are 2 identical copies.
reciprocaltranslocation Reciprocal translocation When a pair of chromosomes exchange exactly the same length and area of DNA. Results in a shuffling of genes.
recombinantclone Recombinant clone Clone containing recombinant DNA molecules.
See also: recombinant DNA technology
recombinantdnamolecules Recombinant DNA molecules A combination of DNA molecules of different origin that are joined using recombinant DNA technologies.
recombinantdnatechnology Recombinant DNA technology Procedure used to join together DNA segments in a cell-free system (an environment outside a cell or organism). Under appropriate conditions, a recombinant DNA molecule can enter a cell and replicate there, either autonomously or after it has become integrated into a cellular chromosome.
recombination Recombination The process by which progeny derive a combination of genes different from that of either parent. In higher organisms, this can occur by crossing over.
See also: crossing over, mutation
Redfieldratio Redfield ratio Optimal ratio of carbon, nitrogen, and phosphorus for phytoplankton growth (106C:16N:1P) based on molecular concentrations.
reduction Reduction Electron-transfer reaction in which a substance gains one or more electrons.
regulatoryelements Regulatory elements Segments of the genome (e.g., regulatory regions, genes that encode regulatory proteins, or small RNAs) involved in controlling gene expression.
regulatoryregionorsequence Regulatory region or sequence Segment of DNA sequence to which a regulatory protein binds to control expression of a gene or group of genes that are expressed together.
reportergene Reporter gene See: marker
resolution Resolution Degree of molecular detail on a physical map of DNA, ranging from low to high.
respiration Respiration Series of biochemical redox reactions in which the energy released from the oxidation of organic or inorganic compounds is used to generate cellular energy in the form of ATP.
restrictionenzyme Restriction enzyme, endonuclease A protein that recognizes specific, short nucleotide sequences and cuts DNA at those sites. Bacteria contain over 400 such enzymes that recognize and cut more than 100 different DNA sequences.
See also: restriction enzyme cutting site
restrictionfragmentlengthpolymorphism Restriction fragment length polymorphism (RFLP) Variation between individuals in DNA fragment sizes cut by specific restriction enzymes; polymorphic sequences that result in RFLPs are used as markers on both physical maps and genetic linkage maps. RFLPs usually are caused by mutation at a cutting site.
See also: marker, polymorphism
restriction-enzymecuttingsite Restriction-enzyme cutting site A specific nucleotide sequence of DNA at which a particular restriction enzyme cuts the DNA. Some sites occur frequently in DNA (e.g., every several hundred base pairs); others much less frequently (rare-cutter; e.g., every 10,000 base pairs).
retroviralinfection Retroviral infection The presence of retroviral vectors, such as some viruses, which use their recombinant DNA to insert their genetic material into the chromosomes of the host's cells. The virus is then propagated by the host cell.
reversetranscriptase Reverse transcriptase An enzyme used by retroviruses to form a complementary DNA sequence (cDNA) from their RNA. The resulting DNA is then inserted into the chromosome of the host cell.
rhizosphere Rhizosphere Narrow zone of soil surrounding a plant root, typically inhabited by microbial community(ies) that interact with the root.
ribonucleotide Ribonucleotide See: nucleotide
ribose Ribose The five-carbon sugar that serves as a component of RNA.
See also: ribonucleic acid, deoxyribose
ribosomal RNA(rRNA) Ribosomal RNA (rRNA) Specialized RNA found in the catalytic core of the ribosome, a molecular machine that synthesizes proteins in all living organisms.
ribosomes Ribosomes Small cellular components composed of specialized ribosomal RNA and protein; site of protein synthesis.
See also: RNA
RNAribonucleicacidRNA RNA (ribonucleic acid) Molecule that plays an important role in protein synthesis and other chemical activities of the cell. RNA's structure is similar to that of DNA. Classes of RNA molecules include messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and other small RNAs, each serving a different purpose.
RNA-Seq RNA-Seq Use of high-throughput sequencing technologies to sequence complementary DNA (cDNA) and obtain information about a sample's RNA content.
ribosomalRNArRNA Ribosomal RNA (rRNA) Specialized RNA found in the catalytic core of the ribosome, a molecular machine that synthesizes proteins in all living organisms.
rootexudate Root exudate Chemical substance released from the root of a plant.
RuBisCo (Ribulose-1,5-bisphosphate carboxylase/oxy­genase) RuBisCo (Ribulose-1,5-bisphosphate carboxylase/oxygenase) Enzyme that catalyzes the first major step of photosynthetic carbon fixation by adding a molecule of carbon dioxide to a short 5-carbon sugar called ribulose bisphosphate. The resulting 6-carbon sugar is split into two 3-carbon molecules that can be used to build larger sugar molecules. RuBisCo also catalyzes photorespiration, which releases CO2.
sangersequencing Sanger sequencing A widely used method of determining the order of bases in DNA.
See also: sequencing, shotgun sequencing
satellite Satellite A chromosomal segment that branches off from the rest of the chromosome but is still connected by a thin filament or stalk.
scaffold Scaffold In genomic mapping, a series of contigs that are in the right order but not necessarily connected in one continuous stretch of sequence.
segregation Segregation The normal biological process whereby the two pieces of a chromosome pair are separated during meiosis and randomly distributed to the germ cells.
senescence Senescence Process of aging.
sequence Sequence See: base sequence
sequenceassembly Sequence assembly A process whereby the order of multiple sequenced DNA fragments is determined.
sequencing Sequencing Determination of the order of nucleotides (base sequences) in a DNA or RNA molecule or the order of amino acids in a protein.
sequencingtechnology Sequencing technology The instrumentation and procedures used to determine the order of nucleotides in DNA.
shotgunmethod Shotgun method Sequencing method that involves randomly sequenced cloned pieces of the genome, with no foreknowledge of where the piece originally came from. This can be contrasted with "directed" strategies, in which pieces of DNA from known chromosomal locations are sequenced.
See also: library, genomic library
simulation Simulation Combination of multiple models into a meaningful representation of a whole system that can be used to predict how the system will behave under various conditions. Simulations can be used to run in silico experiments to gain first insights, form hypotheses, and predict outcomes before conducting more expensive physical experiments.
singlenucleotidepolymorphism Single nucleotide polymorphism (SNP) DNA sequence variations that occur when a single nucleotide (A, T, C, or G) in the genome sequence is altered.
See also: mutation, polymorphism,
solubilitypump Solubility pump System of physical processes [e.g., changes in water temperature, ocean circulation, and gradient of carbon dioxide (CO2) spanning the ocean depth] that influences the ocean's uptake of CO2 from the atmosphere. In combination with ocean circulation, the solubility pump results in net CO2 emissions at the equator and net CO2 drawdown at high latitudes.
southernblotting Southern blotting Transfer by absorption of DNA fragments separated in electrophoretic gels to membrane filters for detection of specific base sequences by radio-labeled complementary probes.
species Species Taxonomic group of closely related organisms sharing structural and physiological features that distinguish them from individuals belonging to other species. In organisms capable of sexual reproduction, individuals of the same species can interbreed and generate fertile offspring. For microorganisms, a species is a collection of closely related strains.
spectralkaryotype Spectral karyotype (SKY) A graphic of all an organism's chromosomes, each labeled with a different color. Useful for identifying chromosomal abnormalities.
See also: chromosome
splicesite Splice site Location in the DNA sequence where RNA removes the noncoding areas to form a continuous gene transcript for translation into a protein.
spodosols Spodosols Acidic soils—typically found in coniferous forests—containing organic matter, aluminum oxides, and iron oxides.
stableisotope Stable isotope Isotope that does not undergo radioactive decay.
stochastic Stochastic Relating to a series of random events.
stoichiometry Stoichiometry Ratio of molecules in a structural complex or chemical reaction.
structuralannotation Structural annotation Process of identifying gene elements such as coding regions, gene structure, regulatory motifs, and open reading frames (ORFs).
See also: genome annotation
structuralgenomics Structural genomics The effort to determine the 3D structures of large numbers of proteins using both experimental techniques and computer simulation
substitution Substitution In genetics, a type of mutation due to replacement of one nucleotide in a DNA sequence by another nucleotide or replacement of one amino acid in a protein by another amino acid.
See also: mutation
superoxidedismutase Superoxide dismutase Enzyme that protects cells from oxidative damage by catalyzing the transformation of superoxide (a harmful species of oxygen) into oxygen and hydrogen peroxide.
suppressorgene Suppressor gene A gene that can suppress the action of another gene.
symbiosis Symbiosis Ecological relationship between two organisms in which both parties benefit.
syndrome Syndrome The group or recognizable pattern of symptoms or abnormalities that indicate a particular trait or disease.
synchrotron Synchrotron Research facility that accelerates charged particles and uses an increasing magnetic field to keep the particles in a circular path. Electromagnetic radiation emitted by the high- energy, accelerated particles can be used in a variety of scientific applications.
syngeneic Syngeneic Genetically identical members of the same species.
synteny Synteny Genes occurring in the same order on chromosomes of different species.
See also: linkage, conserved sequence
syntheticbiology Synthetic biology Field of biological research and technology that combines science and engineering with the goal of designing and constructing new biological functions and systems not found in nature. Essential synthetic biology tools include DNA sequencing, fabrication of genes, modeling how synthetic genes behave, and precisely measuring gene behavior.
systemsbiology Systems biology Use of molecular analyses (e.g., measurements of all genes and proteins expressed in a cell at a particular time) and advanced computational methods to study how networks of interacting biological components determine the properties and activities of living systems.
tandemrepeatsequences Tandem repeat sequences Multiple copies of the same base sequence on a chromosome; used as markers in physical mapping.
See also: physical map
targetedmutagenesis Targeted mutagenesis Deliberate change in the genetic structure directed at a specific site on the chromosome. Used in research to determine the targeted region's function.
See also: mutation, polymorphism
taxa Taxa Categories (e.g., phylum, order, family, genus, or species) used to classify animals and plants. (singular: taxon)
taxonomy Taxonomy Hierarchical classification system for naming and grouping organisms based on evolutionary relationships.
technologytransfer Technology transfer The process of transferring scientific findings from research laboratories to the commercial sector.
telomerase Telomerase The enzyme that directs the replication of telomeres.
telomere Telomere The end of a chromosome. This specialized structure is involved in the replication and stability of linear DNA molecules.
See also: DNA replication
thymine Thymine (T) A nitrogenous base, one member of the base pair AT (adenine-thymine).
See also: base pair, nucleotide
transcript Transcript RNA molecule (mRNA) generated from a gene's DNA sequence during transcription.
transcription Transcription Synthesis of an RNA copy of a gene's DNA sequence; the first step in gene expression.
See also: translation
transcriptionfactor Transcription factor Protein that binds to regulatory regions in the genome and helps control gene expression.
transcriptome Transcriptome Set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA produced in one or a population of cells.
transcriptomics Transcriptomics Global analysis of expression levels of all RNA transcripts present in a cell at a given time.
transfection Transfection The introduction of foreign DNA into a host cell.
See also: cloning vector
transferRNAtRNA Transfer RNA (tRNA) RNA that transports amino acids to ribosomes for incorporation into a polypeptide undergoing synthesis.
transformation Transformation A process by which the genetic material carried by an individual cell is altered by incorporation of exogenous DNA into its genome.
transgenic Transgenic An experimentally produced organism in which DNA has been artificially introduced and incorporated into the organism's germ line.
See also: cell, DNA, gene, nucleus
translation Translation The process in which the genetic code carried by mRNA directs the synthesis of proteins from amino acids.
See also: transcription
translocation Translocation A mutation in which a large segment of one chromosome breaks off and attaches to another chromosome.
See also: mutation
transposableelement Transposable element A class of DNA sequences that can move from one chromosomal site to another.
troposphere Troposphere Region of the atmosphere closest to the Earth's surface.
tussock Tussock A tuft or clump of grass or other vegetation.
ultisols Ultisols Acidic, clay-containing soils with strong horizons found in temperate humid and tropical regions.
uracil Uracil A nitrogenous base normally found in RNA but not DNA; uracil is capable of forming a base pair with adenine.
See also: base pair, nucleotide
VanderWaalsbonds Van der Waals bonds Weak intermolecular bonds resulting from the attraction between electron-rich regions of one molecule and electron-poor regions of another.
vector Vector See: cloning vector
vertisols Vertisols Seasonally dry soils with a high clay content that swell when moist and then crack when dry.
virus Virus A noncellular biological entity that can reproduce only within a host cell. Viruses consist of nucleic acid covered by protein; some animal viruses are also surrounded by membrane. Inside the infected cell, the virus uses the synthetic capability of the host to produce progeny virus.
See also: cloning vector
westernblot Western blot A technique used to identify and locate proteins based on their ability to bind to specific antibodies.
See also: DNA, Northern blot, protein, RNA, Southern blotting
wildtype Wild type The form of an organism that occurs most frequently in nature.
windthrow Windthrow Trees uprooted by wind.
workingdraftdnasequence Working Draft DNA Sequence See: Draft DNA Sequence
yeastartificialchromosome Yeast artificial chromosome (YAC) Constructed from yeast DNA, it is a vector used to clone large DNA fragments.
See also: cloning vector, cosmid
zinc-fingerprotein Zinc-finger protein A secondary feature of some proteins containing a zinc atom; a DNA-binding protein.
zooplankton Zooplankton Free-floating, microscopic animals that drift with water currents.
acronym 2D two dimensional
acronym 3D three dimensional
acronym AEI Advanced Energy Initiative
acronym AFM atomic force microscopy
acronym AGU American Geophysical Union
acronym Al aluminum
acronym ARS Agricultural Research Service, USDA
acronym ASA American Society of Agronomy
acronym ATP adenosine triphosphate
acronym BER Office of Biological and Environmental Research, DOE
acronym BERAC Biological and Environmental Research Advisory Committee
acronym Bgal billion gallons
acronym BNF biological nitrogen fixation
acronym BRET Bioluminescence Resonance Energy Transfer
acronym BSCL Biomass Surface Characterization Laboratory, DOE
acronym BTAC Biomass Research and Development Technical Advisory Committee, DOE-USDA
acronym CAM Crassulacean acid metabolism
acronym CAMERA Community Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis
acronym CBM cellulose-binding molecule, carbohydrate-binding module
acronym CBP consolidated bioprocessing
acronym CDF cumulative distribution function
acronym cDNA complementary DNA
acronym ChIP-Seq chromatin immunoprecipitation sequencing
acronym CO carbon monoxide
acronym CO2 carbon dioxide
acronym CREP Conservation Reserve Enhancement Program
acronym CSSA Crop Science Society of America
acronym CUE carbon use efficiency
acronym CWD coarse woody debris
acronym DGVM dynamic global vegetation model
acronym DMS dimethyl sulfide
acronym DNA deoxyribonucleic acid
acronym DOE U.S. Department of Energy
acronym EERE Office of Energy Efficiency and Renewable Energy, DOE
acronym EIA Energy Information Administration
acronym ELSI ethical, legal, and social issues
acronym EMSL DOE Environmental Molecular Sciences Laboratory
acronym EPAct Energy Policy Act of 2005
acronym EPR electron paramagnetic resonance
acronym eQTL expression quantitative trait locus
acronym EST expressed sequence tag
acronym FER fossil energy-replacement ratio
acronym FT Fischer Tropsch
acronym FT Fourier Transform
acronym FRET fluorescence resonance energy transfer
acronym FTIR Fourier transform infrared (spectroscopy)
acronym GBS genotyping by sequencing
acronym GC gas chromatography
acronym GC-MS gas chromatography-mass spectrometry
acronym GEC Governors' Ethanol Coalition
acronym GH glycosyl hydrolase
acronym GHG greenhouse gas
acronym Genomic Science Genomic Science program, DOE (formerly Genomics:GTL and Genomes to Life)
acronym GOS Global Ocean Sampling
acronym GPP gross primary productivity
acronym GT gigaton
acronym GtC/y gigatons of carbon per year
acronym GTL see Genomic Science
acronym GWAS genome-wide association study
acronym H2 hydrogen
acronym HC hemicellulose
acronym HGT horizontal gene transfer
acronym HI harvest index
acronym HRM Hierarchical Response Model
acronym HTP high throughput
acronym IAM Integrated Assessment Model
acronym IEA International Energy Agency
acronym IMG/M JGI's Integrated Microbial Genome/Metagenome database
acronym IPCC Intergovernmental Panel on Climate Change
acronym IR infrared (spectroscopy)
acronym JGI DOE Joint Genome Institute
acronym KBase DOE Systems Biology Knowledgebase
acronym KIS knowledge integration and synthesis
acronym LC liquid chromatography
acronym LCC lignin carbohydrate complex
acronym LC-MS liquid chromatography-mass spectrometry
acronym LC-MS/MS liquid chromatography-mass spectrometry/mass spectrometry
acronym LIMS laboratory information management system
acronym LPJ-GUESS Lund-Potsdam-Jena General Ecosystem Simulator
acronym Macre million acres
acronym MFD microfluidic device
acronym Mton million tons
acronym Mb megabase
acronym Mg magnesium
acronym Mgal million gallons
acronym MLST multilocus sequence typing
acronym Mn manganese
acronym MOC mineral-associated organic carbon
acronym MSW municipal solid waste
acronym MRI magnetic resonance imaging
acronym MS mass spectrometry, spectroscopy
acronym MVA multivariate analysis
acronym N nitrogen
acronym N2 molecular nitrogen
acronym N2O nitrous oxide
acronym NAD, NADH, NAD(H) nicotinamide adenine dinucleotide
acronym NADP, NADPH, NADP(H) nicotinamide adenine dinucleotide phosphate
acronym NBP net biome productivity
acronym NCEP National Commission on Energy Policy
acronym NEE net ecosystem exchange
acronym NEP net ecosystem productivity
acronym NEP National Energy Policy
acronym NEPDG National Energy Policy Development Group
acronym NERSC National Energy Research Scientific Computing Center
acronym NH3 ammonia
acronym NIH National Institutes of Health
acronym NIR near infrared (spectroscopy)
acronym NMR nuclear magnetic resonance
acronym NPP net primary productivity
acronym NR non redundant
acronym NRC National Research Council
acronym NRDC Natural Resources Defense Council
acronym NREL National Renewable Energy Laboratory, DOE
acronym NSF National Science Foundation
acronym NUE nutrient use efficiency
acronym O2 oxygen
acronym OASCR Office of Advanced Scientific Computing Research, DOE
acronym OBER see BER
acronym OBP Office of the Biomass Program, DOE
acronym OIT Office of Industrial Technologies, DOE
acronym P phosphorus
acronym pCO2 partial pressure of carbon dioxide
acronym PCR polymerase chain reaction
acronym PDF probability density function
acronym PFT plant functional type
acronym Pg petagram
acronym POC particulate organic carbon
acronym ppmv parts per million by volume
acronym QTL quantitative trait locus
acronym Ra autotrophic respiration
acronym Rd respiration by decomposers
acronym RDDD&D research, development, demonstration, deployment, and decommissioning
acronym RFA Renewable Fuels Association
acronym R&D research and development
acronym Rh heterotrophic respiration
acronym RI recombinant inbred
acronym RNA ribonucleic acid
acronym rRNA ribosomal RNA
acronym ROS reactive oxygen species
acronym Rs respiration by plant roots and soil heterotrophs
acronym S sulfur
acronym SC Office of Science, DOE
acronym SEM scanning electron microscopy
acronym Si silicon
acronym SNP single nucleotide polymorphism
acronym SOC soil organic carbon
acronym SOD superoxide dismutase
acronym SOM soil organic matter
acronym SPR surface plasmon resonance
acronym SSF simultaneous saccharification and fermentation
acronym SSCF simultaneous saccharification and cofermentation
acronym SSR simple sequence repeat
acronym SSSA Soil Science Society of America
acronym ssu rRNA small subunit ribosomal RNA
acronym TDF transcript-derived fragments
acronym T-DNA transferred DNA
acronym TEM transmission electron microscopy
acronym TIGR The Institute for Genomic Research
acronym TMS theory, modeling, and simulation
acronym TOF time of flight
acronym USDA U.S. Department of Agriculture
acronym UV ultraviolet
acronym Vmax maximum enzyme velocity
acronym WUE water use efficiency

Updated December 6, 2012

Decimal Units
10+18 exa
10+15 peta
10+12 tera
10+9 giga
10+6 mega
10+3 kilo
100 ----
10-3 milli
10-6 micro
10-9 nano
10-12 pico
10-15 femto
10-18 atto

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